Chapter 1 Cancer Epidemiology 1
Article ACurrent Cancer Situation in China：Good or Bad News From the 2018 Global Cancer Statistics？1
Word Study1
From Sentence to Discourse — Long Sentences7
Comprehension of Different Sections9
Reading Strategies：Identifying Article Types15
Activity16
Article BPro-Inflammatory Diet as a Risk Factor for Stomach Cancer：Findings from a Multicenter Study in Central and Western China17
Word Study17
From Sentence to Discourse — Noun Phrases22
Comprehension of Different Sections25
Reading Strategies：How to Choose the Right Article to Read?30
Activity32

Chapter 2 Cancer Pathogenesis 34
Article AThe Hallmarks of Cancer34
Word Study34
From Sentence to Discourse — Metaphor39
Comprehension of Different Sections41
Reading Strategies：How to Read Articles Critically?48
Activity50
Article BTranscription Factor NFIB is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients51
Word Study51
From Sentence to Discourse — Rhetoric Moves56
Comprehension of Different Sections57
Reading Strategies：The Anatomy of a Scholarly Article62
Activity64

Chapter 3 Chemotherapy 66
Article AChemotherapy and the War on Cancer66
Word Study66
From Sentence to Discourse — Nominalization72
Comprehension of Different Sections75
Reading Strategies：Reading Titles and Abstracts80
Activities82
Article BChromosomal Instability Sensitizes Patient Breast Tumors to Multipolar Divisions Induced by Paclitaxel84
Word Study84
From Sentence to Discourse — Grammatical Cohesion89
Comprehension of Different Sections91
Reading Strategies：Reading Introduction96
Activity97

Chapter 4 Targeted Therapy 99
Article ATargeted Therapies：A New Generation of Cancer Treatments99
Word Study99
From Sentence to Discourse — Thematic Progress105
Comprehension of Different Sections107
Reading Strategies：Reading Materials and Methods113
Activity114
Article BTrastuzumab（herceptin），a Humanized Anti-HER2 Receptor Monoclonal Antibody，Inhibits Basal and Activated HER2 Ectodomain Cleavage in Breast Cancer Cells117
Word Study117
From Sentence to Discourse — First Person Pronouns123
Comprehension of Different Sections125
Reading Strategies：Reading Results130
Activity131

Chapter 5 Immunotherapy 133
Article APD-1 Pathway Inhibitors：the Next Generation of Immunotherapy for Advanced Melanoma133
Word Study133
From Sentence to Discourse — Passive Voice138
Comprehension of Different Sections140
Reading Strategies：Reading Discussion and Conclusion144
Activities145
Article BThe Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+T Cell Effector Function148
Word Study148
From Sentence to Discourse — Tense Shift153
Comprehension of Different Sections154
Reading Strategies：Reading References158
Activity160

Chapter 6 Gene Therapy and Cell Therapy 163
Article AFrom Bench to Bedside：the History and Progress of CAR T-Cell Therapy163
Word Study163
From Sentence to Discourse — Lexical Cohesion168
Comprehension of Different Sections170
Reading Skills：Expanding Medical and Pharmaceutical Terminology174
Practice177
Article BInduction of Durable Antitumor Response by a Novel Oncolytic Herpesvirus Expressing Multiple Immunomodulatory Transgenes178
Word Study178
From Sentence to Discourse — Third-person Writing183
Comprehension of Different Sections186
Reading Skills：Reading Tables and Figures191
Activity192

Chapter 7 Cancer Drug Discovery 194
Article ASmall-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics194
Word Study194
From Sentence to Discourse — Coherence200
Comprehension of Different Sections202
Reading Skills：Working with Context Clues208
Practice209
Article BPreclinical Pharmacokinetics，Pharmacodynamics，and Efficacy of RG7116：a Novel Humanized，Glycoengineered Anti-HER3 Antibody212
Word Study212
From Sentence to Discourse — Hedges217
Comprehension of Different Sections220
Reading Skills：Main Idea and Details224
Practice226

Chapter 8 Clinical Development 228
Article AChanges in Clinical Trials of Cancer Drugs in Mainland China over the Decade 2009-2018：a Systematic Review228
Word Study229
From Sentence to Discourse — The Pairing of Inanimate Subjects with Animate Verbs234
Comprehension of Different Sections236
Reading Skills：Differentiating Facts from Opinions241
Practice243
Article BErlotinib Versus Standard Chemotherapy as First-line Treatment for European Patients with Advanced EGFR Mutation-positive Non-small-cell Lung Cancer（EURTAC）：a Multicentre，Open-label，Randomised Phase 3 Trial245
Word Study245
From Sentence to Discourse — Parenthetical Expression252
Comprehension of Different Sections254
Reading Skills：Sequencing Events258
Practice260

Chapter 9 Drug Approval and Marketing 261
Article AAn overview of cancer drugs approved through expedited approval programs and orphan medicine designation globally between 2011 and 2020261
Word Study262
From Sentence to Discourse — It-clauses267
Comprehension of Different Sections269
Reading Skills：Taking Notes275
Practice277
Article BAccelerated Approval for Cancer Drugs in the United States and the Clinical Evidence Required for Conversion to Regular Approval278
Word Study278
From Sentence to Discourse — Non-finite Clauses284
Comprehension of Different Sections287
Reading Skills：Understanding Cause and Effect Relationships293
Activities295

Chapter 10 Generics and biosimilars 297
Article AThe Rise of Oncology Biosimilars：from Process to Promise297
Word Study297
From Sentence to Discourse — Authorial Stance302
Comprehension of Different Sections305
Reading Skills：Summarizing310
Practice311
Article BNew Cutaneous Toxicities with Generic Docetaxel：Are the Excipients Guilty？313
Word Study313
From Sentence to Discourse — Inverted Sentences317
Comprehension of Different Sections320
Reading Skills：Comparing and Contrasting325
Practice326